Computational prediction of ADMET properties of ACAT inhibitors for synthesis and pharmacological screening

As we know ACAT enzyme is responsible for the catalysis of cholesterol into cholesteryl esters leading to Hyperlipidemia which directly linked with cardiac problems. Throughout world problems are causing increased mortality. This study aims synthesize and screen pharmacologically active compound from best five compounds docked having good binding affinity found in our earlier research against enzyme. The were detected their ADME value by SwissADME software checked toxicity level via ProTox-II server showing antihyperlipidemic effect For pharmacological screening rats fed High Fat Diet then evaluated Atorvastatin (10 mg/kg) was used as standard drug test compound. Blood samples collected at 28th day. Serum separated analyzed lipid profile, using diagnostic reagent kits. results demonstrated that synthetic C10 raised concentration high-density lipoprotein serum while lowering total cholesterol, triglycerides, low-density lipoprotein. possess activity.